The campus of St. Stephen's occupies two and one-half acres in the center of historic Rome. Constructed around a central courtyard, the traditional Roman-style building contains 12 classrooms, two art studios, a music room, three science laboratories, a 13,500 volume automated library (including a collection of CD ROMs, videos, microfiche, periodicals, INTERNET access), a computer room and writing center, a multimedia center, photography laboratory, dining room, snack bar and students' lounge, laundry room, theater/auditorium, dormitory rooms, resident faculty apartments, tennis, basketball and volleyball courts.

All classrooms, laboratories, studios, dormitory rooms and faculty apartments have computer network access for Internet and CD-rom research.

St. Stephen's is located next door to the United Nations Food and Agriculture Organization, diagonally across from the Circus Maximus, and a short walk from the Colosseum and the Roman Forum, the Pyramid of Caius Cestius and the Baths of Caracalla.

The school is easily reached by the line B of the metro (Circo Massimo stop), city buses (673, 75, 175, 715, 628), the 3 tram line and commuter trains running from Termini and Ostiense stations.